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The active substance in Carelio is metoprolol. Metoprolol belongs to the group of medicines called beta-blockers and is used for the treatment of high blood pressure (hypertension), the long term treatment of angina pectoris (tightness in the chest), chronic heart failure (chronic cardiac insufficiency), heart rhythm disorders and cardiovascular disorders with palpitations, as well as for the prevention of migraine. Due to its special formulation, which allows controlled release of the active substance, the effect of Carelio prolonged-release tablets usually lasts 24 hours. Carelio may be taken only when prescribed by a doctor and with ongoing medical monitoring. How to use Carelio prolonged-release tablets are taken once daily with a glass of water. They can be taken with or without meals. The Carelio prolonged-release tablets have a score line and can be easily divided. However, they must not be crushed or chewed. The doctor will prescribe the right dose for you based on regular tests/examinations. In general, the following dosage guidelines apply: High blood pressure (hypertension) Adults In cases of mild to moderate high blood pressure, take 1 prolonged-release tablet of Carelio 50, once daily in the morning. The dosage may be increased by the doctor to 1 prolongedrelease tablet of Carelio 100 or Carelio 200. If necessary, your doctor may prescribe an additional blood-pressure lowering medicine for you. For children from 6 years of age, the dosage depends on body weight. Your doctor will determine the correct dosage for your child and monitor it regularly. Children and adolescents (6 to 16 years of age) The use of Carelio by children below 6 years of age is not recommended. Angina pectoris (tightness in the chest) In cases of angina pectoris, take 1 prolonged-release tablet of Carelio 100 or Carelio 200 once daily. If necessary, your doctor may increase the dose. Chronic heart failure (chronic cardiac insufficiency) In cases of chronic heart failure, the initial dose is Carelio 25 mg once daily for 2 weeks. In cases of severe heart failure, the doctor may prescribe you a lower initial dose of 12.5 mg once daily (half a Carelio 25 mg prolonged-release tablet). The dose can then be doubled every two weeks up to 200 mg Carelio once daily. Heart rhythm disorders In cases of heart rhythm disorders, take 1 prolonged-release tablet of Carelio 100 or Carelio 200 once daily. If necessary, your doctor may increase the dose. Cardiovascular disorders with palpitations In cases of cardiovascular disorders, take 1 prolonged-release tablet of Carelio 100 once daily. If necessary, your doctor may increase the dose. Prevention of migraine For the prevention of migraine, take 1 prolonged-release tablet of Carelio 100 or Carelio 200 once daily. Warnings and precautions When must Carelio not be used? Carelio must not be taken if you have a known hypersensitivity to the active substance metoprolol, to any of the other ingredients or to any other medicines that belong to the group called beta-blockers. In addition, Carelio must not be taken: If you have problems with the passage of electrical impulses from the heart’s upper chambers (atria) to the lower chambers (ventricles) (2nd- and 3rd) If you have an irregular heartbeat which is often very slow and sometimes very fast (except if you have a permanent pacemaker), If you have problems with the passage of electrical impulses between the sinus node and upper chamber of the heart (atrium), If you are suffering from shock, If you have a weak heart together with fluid accumulation in the lungs, poor blood circulation or low blood pressure, If your resting pulse rate before treatment is less than 50 beats per minute, If you have abnormally low blood pressure, If the circulation in your arms or legs is severely reduced, If you are prone to bronchial asthma or bronchial spasms. When caution is needed while taking Carelio? This medicine may affect your reactions, your ability to use tools and machinery and your ability to drive. If you are taking other medicines for breathing disorders at the same time, the dosages of the various medicines must be readjusted by a doctor. Caution is advised in case of diabetes mellitus, certain heart conditions, heart conduction disorders, circulatory disorders, impaired liver function as well as in patients with a hormoneproducing tumour (phaeochromocytoma). Before surgery the anaesthetist should be informed that you are taking Carelio . Some medications (including nose and eye drops) as well as alcohol may interfere with the action of Carelio if taken at the same time. Side Effects The following side effects may occur when taking Carelio: Very common: tiredness. Common: dizziness, headache, nausea, abdominal pain, shortness of breath, abnormally slow pulse, cold hands and feet, diarrhoea and constipation. Storage Information Do not store above 25°C Ingredients 1 prolonged-release tablet of Carelio 25, 50, 100 and 200 contains 23.75 mg, 47.5 mg, 95 mg and 190 mg respectively of metoprolol succinate, equivalent to 25 mg, 50 mg, 100 mg and 200 mg respectively of metoprolol tartrate.
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