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The active ingredient in CLAZ MR is gliclazide. Gliclazide belongs to a group of medicines called the sulfonylureas. Gliclazide lowers high blood glucose by increasing the amount of insulin produced by your pancreas. Glucose is used by the body as fuel, and all people have glucose circulating in their blood. The medicine is used to control blood glucose in patients with Type II diabetes mellitus. This type of diabetes is also known as non-insulin-dependent diabetes mellitus (NIDDM) or maturity onset diabetes. CLAZ MR is used when diet and exercise are not enough to control your blood glucose. CLAZ MR can be used alone, or together with other medicines for treating diabetes. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. In diabetes, levels of blood glucose are higher than is needed. This is called hyperglycemia. A section at the end of this leaflet contains advice about recognizing and treating hyperglycemia. It is very important to control high blood glucose whether or not you feel unwell. This really helps to avoid serious long-term health problems, which can involve the heart, eyes, circulation, and/or kidneys. As with many medicines used for the treatment of diabetes, there is a possibility that blood glucose levels may become very low during treatment with gliclazide. This is known as hypoglycemia. A section at the end of this leaflet contains advice about recognizing and treating hypoglycemia. There is no evidence that this medicine is addictive. How to use How much CLAZ MR to take Your doctor or pharmacist will tell you how much of this medicine you should take. This will depend on your condition and whether you are taking any other medicines. The starting dose is usually 30 mg per day. This will be adjusted slowly over several weeks, depending on how well your body responds to the dose. The usual dose of this medicine may vary from one to four tablets each day. Your doctor may increase or decrease the dose, depending on your blood glucose levels. Do not stop taking your medicine or change your dosage without first checking with your doctor. How and When to take CLAZ MR Swallow the tablets whole with a glass of water. Do not crush the tablets or break them. Take it at about the same time each day, usually with breakfast. Taking these tablets with food can help to minimize the risk of hypoglycemia. It will also help you remember when to take them. Do not skip meals while taking these tablets. Warnings and precautions Do not take CLAZ MR if The expiry date (EXP) printed on the pack has passed The packaging is torn, shows signs of tampering or it does not look quite right You have Type I diabetes mellitus (insulin dependent diabetes mellitus, also known as IDDM, or juvenile or growth onset diabetes) You have unstable or brittle diabetes You have diabetic acidosis You have diabetic coma or pre-coma You have a history of repeated ketoacidosis or coma You have severe kidney disease You have severe liver disease. Take special care Remember to keep checking your blood glucose levels. Before you start taking this medicine, tell your doctor if you: Have allergies to any other medicines or any other substances, such as foods, preservatives or dyes. Have or have had any medical conditions, especially the following: Kidney problems Liver problems A growth in your pancreas, called an insulinoma A history of diabetic coma adrenal, pituitary or thyroid problems Heart failure A condition called Glucose-6- Phosphate dehydrogenase Deficiency (G6PD) Side Effects This list includes the more common side effects. Mostly, these are mild: stomach upset including nausea and vomiting (feeling or being sick), heartburn, diarrhoea, constipation or a feeling of fullness in the stomach sight problems (this may happen when you first start taking this medicine and your blood sugar levels change) weariness dizziness or giddiness headache mild rash or redness of the skin. These may be serious side effects. You may need medical attention. Most of these side effects are rare. hypoglycemia or hyperglycemia. signs of frequent or worrying infections such as fever, severe chills, sore throat or mouth ulcers signs of anemia such as tiredness, being short of breath and looking pale bleeding or bruising more easily than normal, reddish or purplish blotches under the skin itchy, red veins. Storage Information Keep your medicine in a cool dry place where the temperature will stay below 30°C. Protect it from moisture. Drug Interactions Some medicines may interact with CLAZ MR. These include: Other medicines used to treat diabetes (tablets and insulin) Some medicines used to treat high blood pressure and other heart conditions, such as beta-blockers, ace inhibitors Some hormones used in hormone replacement therapy and oral contraceptives (oestrogens and progestogens) Monoamine oxidase inhibitors (maois), used for treating depression, parkinsons disease or infections Some medicines used for mental illness (e.G. Chlorpromazine) Some medicines for epilepsy such as phenobarbitone Clofibrate, a medicine for lowering cholesterol Antibiotics called sulfonamides, or chloramphenicol Miconazole, or fluconazole, used to treat fungal infections Ingredients Each tablet contains 60 mg of gliclazide as the active ingredient.
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