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Esomeprazole magnesium Delayed Release Capsules contains a medicine called esomeprazole. This belongs to a group of medicines called ‘proton pump inhibitors’. They work by reducing the amount of acid that your stomach produces. Esomeprazole magnesium Delayed Release Capsules is used to treat the following conditions: Adults ‘Gastroesophageal reflux disease’ (GERD). This is where acid from the stomach escapes into the gullet (the tube which connects your throat to your stomach) causing pain, inflammation and heartburn. Ulcers in the stomach or upper part of the gut (intestine) that are infected with bacteria called ‘Helicobacter pylori’. If you have this condition, your doctor may also prescribe antibiotics to treat the infection and allow the ulcer to heal. Stomach ulcers caused by medicines called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). Esomeprazole magnesium Delayed Release Capsules can also be used to stop stomach ulcers from forming if you are taking NSAIDs. Too much acid in the stomach caused by a growth in the pancreas (Zollinger-Ellison syndrome). Prolonged treatment after prevention of rebleeding of ulcers with intravenous Esomeprazole magnesium Delayed Release Capsules. Adolescents aged 12 years and above ‘Gastroesophageal reflux disease’ (GERD). This is where acid from the stomach escapes into the gullet (the tube which connects your throat to your stomach) causing pain, inflammation and heartburn. Ulcers in the stomach or upper part of the gut (intestine) that are infected with bacteria called ‘Helicobacter pylori’. If you have this condition, your doctor may also prescribe antibiotics to treat the infection and allow the ulcer to heal. How to use To treat heartburn caused by gastroesophageal reflux disease (GERD): If your doctor has found that your food pipe (gullet) has been slightly damaged, the recommended dose is one Esomeprazole magnesium Delayed Release Capsules 40 mg gastro-resistant capsule once a day for 4 weeks. Your doctor may tell you to take the same dose for a further 4 weeks if your gullet has not yet healed. The recommended dose once the gullet has healed is one Esomeprazole magnesium Delayed Release Capsules 20 mg gastro-resistant capsule once a day If your gullet has not been damaged, the recommended dose is one Esomeprazole magnesium Delayed Release Capsules 20 mg gastro-resistant capsule each day. Once the condition has been controlled, your doctor may tell you to take your medicine as and when you need it, up to a maximum of one Esomeprazole magnesium Delayed Release Capsules 20 mg gastro-resistant capsule each day. Warnings and precautions Do not take Esomeprazole magnesium Delayed Release Capsules: If you are allergic to esomeprazole or any of the other ingredients of this medicine (listed in section 6). If you are allergic to other proton pump inhibitor medicines (e.g. pantoprazole, lansoprazole, rabeprazole, omeprazole). If you are taking a medicine containing nelfinavir (used to treat HIV infection). Warnings and precautions Talk to your doctor or pharmacist before taking Esomeprazole magnesium Delayed Release Capsules: If you have severe liver problems. If you have severe kidney problems. If you have ever had a skin reaction after treatment with a medicine similar to Esomeprazole magnesium Delayed Release Capsules that reduces stomach acid. If you are due to have a specific blood test (Chromogranin A). Side Effects If you notice any of the following serious side effects, stop taking Esomeprazole magnesium Delayed Release Capsules and contact a doctor immediately: Sudden wheezing, swelling of your lips, tongue and throat or body, rash, fainting or difficulties in swallowing (severe allergic reaction). Reddening of the skin with blisters or peeling. There may also be severe blisters and bleeding in the lips, eyes, mouth, nose and genitals. This could be ‘Stevens-Johnson syndrome’ or ‘toxic epidermal necrolysis’. Yellow skin, dark urine and tiredness which can be symptoms of liver problems. These effects are rare, and may affect up to 1 in 1,000 people. Other side effects include: Common (may affect up to 1 in 10 people) Headache. Effects on your stomach or gut: diarrhoea, stomach pain, constipation, wind (flatulence). Feeling sick (nausea) or being sick (vomiting). Benign polyps in the stomach. Storage Information Store below 30°C. Drug Interactions Tell your doctor or pharmacist if you are taking any of the following medicines: Atazanavir (used to treat HIV infection). Clopidogrel (used to prevent blood clots). Ketoconazole, itraconazole or voriconazole (used to treat infections caused by a fungus). Erlotinib (used to treat cancer). Citalopram, imipramine or clomipramine (used to treat depression). Diazepam (used to treat anxiety, relax muscles or in epilepsy). Phenytoin (used in epilepsy). If you are taking phenytoin, your doctor will need to monitor you when you start or stop taking Esomeprazole magnesium Delayed Release Capsules. Medicines that are used to thin your blood, such as warfarin. Your doctor may need to monitor you when you start or stop taking Esomeprazole magnesium Delayed Release Capsules. Ingredients The active substance is Esomeprazole.\
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