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Glemax is a medicine taken by mouth to help lower blood sugar. It belongs to a group of medicines called sulfonylureas. Glemax works by increasing the amount of insulin released from your pancreas. The insulin then lowers your blood sugar levels. What Glemax is used for: Glemax is used to treat a certain form of diabetes (type 2 diabetes mellitus) when diet, physical exercise and weight reduction alone have not been able to control your blood sugar levels. How to use Taking this medicine: Take this medicine by mouth, just before or with the first main meal of the day (usually breakfast). If you do not have breakfast you should take the medicine on schedule as prescribed by your doctor. It is important not to leave out any meal when you are on Glemax. Swallow the tablets with at least half glass of water. Do not crush or chew the tablets. How much to take: The dose of Glemax depends on your needs, condition and results of blood and urine sugar tests and is determined by your doctor. Do not take more tablets than your doctor has prescribed. The usual starting dose is one Glemax 1 mg tablet once a day. If necessary, your doctor may increase the dose after each 1 - 2 weeks of treatment. The maximum recommended dose is 6 mg Glemax per day A combination therapy of Glimepiride plus metformin or of Glimepiride plus insulin may be started. In such a case your doctor will determine the proper doses of Glimepiride, metformin or insulin individually for you. Your dose of Glemax may need to be adjusted if you change weight, change your lifestyle, or if you are under a lot of stress. Please speak to your doctor if any of these situations apply to you. Warnings and precautions Do not take Glemax if: You are allergic to: Glimepiride or other sulfonylureas (medicines used to lower your blood sugar such as glibenclamide) or sulfonamides (medicines for bacterial infections such as sulfamethoxazole) or any of the other ingredients of this medicine. You have insulin dependent diabetes (type 1 diabetes mellitus). You have diabetic ketoacidosis (a complication of diabetes when your acid level is raised in your body and you may have some of the following signs: fatigue, feeling sick (nausea), frequent urination and muscular stiffness). You are in a diabetic coma. You have severe kidney disease. You have a severe liver disease. Do not take this medicine if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking. Glemax. Take special care with Glemax: You are recovering from an injury, operation, infections with fever, or from other forms of stress, inform your doctor as temporary change of treatment may be necessary. You have a severe liver or kidney disorder. Side Effects Tell your doctor immediately if you experience any of the following symptoms: Allergic reactions (including inflammation of blood vessels, often with skin rash) which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock. Abnormal liver function including yellowing of the skin and eyes (jaundice), problems with the bile flow (cholestasis), inflammation of the liver (hepatitis) or liver failure. Allergy (hypersensitivity) of the skin such as itching, rash, hives and increased sensitivity to sun. Some mild allergic reactions may develop into serious reactions. Severe hypoglycemia including loss of consciousness, seizures or coma. Some patients experienced the following side effects whilst taking Glemax: Rare side effects (may affect up to 1 in 1,000 people): Lower blood sugar than normal (hypoglycemia) (see section 2). Decrease in the number of blood cells: Blood platelets (which increases risk of bleeding or bruising). White blood cells (which makes infections more likely). Red blood cells (which can make the skin pale and cause weakness or breathlessness). Storage Information This medicinal product does not require any special storage conditions. Store below 30°C. Drug Interactions The following medicines can increase the blood sugar lowering effect of Glemax. This can lead to a risk of hypoglycemia (low blood sugar): Other medicines to treat diabetes mellitus (such as insulin or metformin). Medicines to treat pain and inflammation (phenylbutazone, azopropazone, oxyphenbutazone, aspirin-like medicines). Medicines to treat urinary infections (such as some long acting sulfonamides). Medicines to treat bacterial and fungal infections (tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin). Medicines to inhibit blood clotting (coumarin derivatives such as warfarin). Medicines supporting muscle build up (anabolics). Medicines used for male sex hormone replacement therapy. Medicines to treat depression (fluoxetine, MAO-inhibitors). Medicines lowering high cholesterol level (fibrates). Medicines lowering high blood pressure (ACE inhibitors). Medicines called anti-arrhythmic agents used to control abnormal heart beat (disopyramide). Medicines to treat gout (allopurinol, probenecid, sulfinpyrazone). Medicines to treat cancer (cyclophosphamide, ifosfamide, trofosfamide). Medicines used to reduce weight (fenfluramine). Medicines to increase circulation when given in a high dose intravenous infusion (pentoxifylline). Ingredients Glemax 1 contains 1mg of Glimepiride. The other ingredients are: Lactose, Microcrystalline Cellulose, Povidone, Sodium Starch Glycolate, Sepitrap (Ethoxylated Hydrogenated Castor Oil), Magnesium Stearate.
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