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Glim is an orally active blood sugar lowering drug. This drug belongs to a blood sugar lowering group of medicines called sulfonylurea. Glim works by increasing the amount of insulin released from your pancreas. The insulin then lowers your blood sugar levels. Glim is used to treat a certain form of diabetes (type 2 diabetes mellitus) when diet, physical exercise and weight reduction alone have not been able to control your blood sugar levels. How to use Taking this medicine Take this medicine by mouth, just before or with the first main meal of the day. If you do not have breakfast you should take the product on schedule as prescribed by your doctor. It is important not to leave out any meal when you are on Glim. Swallow the tablets whole with at least half glass of water. Do not crush or chew the tablets. How much to take The dose of Glim depends on your needs, condition and results of blood and urine sugar tests and is determined by your doctor. Do not take more tablets than your doctor has prescribed. The usual starting dose is one Glim 1 mg tablet once a day. If necessary, your doctor may increase the dose after each 1 - 2 weeks of treatment. The maximum recommended dose is 6 mg Glim per day. A combination therapy of glimepiride plus metformin or of glimepiride plus insulin may be initiated. In such a case your doctor will determine the proper doses of glimepiride, metformin or insulin individually for you. If your weight changes or if you change your lifestyle, or you are in a stress situation this may require changed Glim doses, therefore inform your doctor. If you feel the effect of your medicine is too weak or too strong do not change the dose yourself, but ask your doctor. Warnings and precautions Do not take Glim and tell your doctor if: You are allergic (hypersensitive) to: Glimepiride or other sulfonylureas (medicines used to lower your blood sugar such as glibenclamide) or sulfonamides (medicines for bacterial infections such as sulfamethoxazole) or any of the other ingredients of Glim (listed in Section 6 What Glim contains). You have insulin dependent diabetes (type 1 diabetes mellitus). You have diabetic ketoacidosis (a complication of diabetes when your acid level is raised in your body and you may have some of the following signs: fatigue, feeling sick (nausea), frequent urination and muscular stiffness). You are in a diabetic coma. You have severe kidney disease. You have a severe liver disease. General: Macrovascular outcomes: There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction. Take special care with Glim Check with your doctor or pharmacist before taking your medicine if: You are recovering from an injury, operation, infections with fever, or from other forms of stress, inform your doctor as temporary change of treatment may be necessary. You have a severe liver or kidney disorder. If you are not sure if any of these apply to you, talk to your doctor or pharmacist before taking Glim . Lowering of the haemoglobin level and breakdown of red blood cells (haemolytic anemia) can occur in patients missing the enzyme glucose-6-phosphate dehydrogenase. The information available on the use of Glim in people less than 18 years of age is limited. Therefore, its use in these patients is not recommended. Side Effects Tell your doctor immediately if you experience any of the following symptoms: Allergic reactions (including inflammation of blood vessels, often with skin rash) which may develop into serious reactions with difficulty in breathing, fall in blood pressure and sometimes progressing to shock. Abnormal liver function including yellowing of the skin and eyes (jaundice), problems with the bile flow (cholestasis), inflammation of the liver (hepatitis) or liver failure. Allergy (hypersensitivity) of the skin such as itching, rash, hives and increased sensitivity to sun. Some mild allergic reactions may develop into serious reactions. Severe hypoglycaemia including loss of consciousness, seizures or coma. Storage Information Do not store above 30°C. Store in the original package. Drug Interactions The following medicines can increase the blood sugar lowering effect of Glim . This can lead to a risk of hypoglycaemia (low blood sugar): Other medicinal products to treat diabetes mellitus (such as insulin or metformin). Medicinal products to treat pain and inflammation (phenylbutazone, azopropazone, oxyphenbutazone, aspirin-like medicines). Medicinal products to treat urinary infections (such as some long acting sulfonamides). Medicinal products to treat bacterial and fungal infections (tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin). Medicinal products to inhibit blood clotting (coumarin derivatives such as warfarin). Medicinal products supporting muscle build up (anabolics). Medicinal products used for male sex hormone replacement therapy. Medicinal products to treat depression (fluoxetine, MAO-inhibitors). Medicinal products lowering high cholesterol level (fibrates). Medicinal products lowering high blood pressure (ACE inhibitors). Ingredients The active substance is 1, 2, 3, 4 or 6 mg of glimepiride. Glim 3mg Tablets: Lactose BP 200, sodium starch glycolate, magnesium stearate, Povidone K-30, Avicel PH 101 and Iron Oxide Red.
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