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Glucare XR 500mg (30 tablets) is an oral antidiabetic medication used primarily to manage type 2 diabetes mellitus. It contains Metformin Hydrochloride in an extended-release (XR) formulation, designed to release the active ingredient slowly into the body to improve gastrointestinal tolerance and allow for convenient once-daily dosing. Key Product Details Active Ingredient: Metformin Hydrochloride 500mg. Formulation: Extended-release (XR) tablets, which minimize side effects like nausea and diarrhea compared to immediate-release versions. Manufacturer: Produced by Jazeera Pharmaceutical Industries (JPI). Appearance: White to off-white, capsule-shaped, concave tablets embossed with 'JI172' on one side. Main Uses & Benefits Blood Sugar Control: Lowers blood glucose by reducing the amount of sugar produced by the liver and decreasing intestinal absorption. Insulin Sensitivity: Improves the body's natural response to insulin, helping peripheral tissues use glucose more effectively. Prevention: Used in overweight adults at high risk of developing type 2 diabetes when lifestyle changes (diet and exercise) alone are insufficient. Weight Management: Often associated with stable body weight or modest weight loss. Usage and Dosage Standard Starting Dose: Typically one 500mg tablet taken once daily with the evening meal. Administration: Swallow the tablet whole with water. Do not crush, cut, or chew, as this destroys the extended-release mechanism. Maximum Dose: Generally up to 2,000mg (four 500mg tablets) per day. Safety & Precautions Common Side Effects: Diarrhea, nausea, vomiting, stomach ache, or loss of appetite (usually resolve within 2 weeks). Rare but Serious Risk: Lactic acidosis is a rare but life-threatening complication; seek immediate medical attention if you experience extreme weakness, trouble breathing, or slow heartbeat. Contraindications: Do not use if you have severe kidney failure, liver problems, or are acutely dehydrated. Alcohol: Avoid excessive alcohol consumption while taking this medication as it increases the risk of lactic acidosis.
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