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Jazofen is an anti-inflammatory pain killer. It is used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis (including juvenile rheumatoid arthritis or Still’s disease), arthritis of the spine (ankylosing spondylitis), swollen joints, frozen shoulder, bursitis, tendinitis, tenosynovitis, lower back pain, sprains and strains. Jazofen can also be used to treat other painful conditions such as toothache, pain after operations, period pain and headache, including migraine. How to use Always take Jazofen exactly as your doctor or healthcare provider has told you. You should check with your doctor, healthcare provider or pharmacist if you are not sure. Take your Jazofen with or after food, with a glass of water. Jazofen should be swallowed whole and not chewed, broken, crushed or sucked to help prevent discomfort in the mouth or irritation in the throat. The usual doses are: Adults: The usual dosage is 600 to 1800 mg spread throughout the day. Your doctor may choose to increase this depending on what you are being treated for, but no more than 2400 mg should be taken in one day. Children: The usual daily dosage is 20 mg per kg of bodyweight, given in divided doses. Jazofen should not be taken by children weighing less than 7 kg. In cases of severe juvenile arthritis your doctor may increase the dosage up to 40 mg/kg in divided doses. Warnings and precautions Do not take Jazofen Your doctor or healthcare provider should know if: You are allergic (hypersensitive) to ibuprofen or any of the other ingredients of Jazofen; You have, or have you previously had, a stomach ulcer or other gastric complaint. Do not take Jazofen if you currently have a peptic ulcer (ulcer in your stomach or duodenum) or bleeding in your stomach, or have had two or more episodes of peptic ulcers, stomach bleeding or perforation in the past; You have a condition which increases your tendency to bleeding; You suffer from asthma or have you ever had an allergic reaction or suffered from wheezing after taking ibuprofen, aspirin or other anti- inflammatory pain killers. You suffer from severe heart failure, hepatic failure and renal failure. You are more than six months pregnant. Take special care with Jazofen Your doctor or healthcare provider should know if: You are less than six months pregnant or planning to become pregnant, or you are breast-feeding. Jazofen may make it more difficult to become pregnant. You should inform your doctor if you are planning to become pregnant or if you have problems becoming pregnant; You suffer from liver or kidney disease; You suffer from heart disease. Medicines such as Jazofen may be associated with a small increased risk of heart attack (myocardial infarction) or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment. You have systemic lupus erythematosus (SLE, some- times known as lupus) or a connective tissue disease (autoimmune diseases affecting connective tissue). Side Effects If you suffer from any of the following at any time during your treatment stop taking Jazofen and seek immediate medical help: severe headache, high temperature, stiffness of the neck or intolerance to light; pass blood in your faeces (stools/motions); pass black tarry stools; vomit any blood or dark particles that look like coffee grounds. Tell your doctor and stop taking the tablets if you experience: unexplained stomach pain or other abnormal stomach symptoms, indigestion, heartburn, feeling sick and/or vomiting; unexplained wheezing, shortness of breath, skin rash, itching or bruising; Jazofen-v1.0 2 04.03.2013 yellowing of the eyes and/or skin; severe sore throat with high fever; blurred or disturbed vision or seeing/hearing strange things; fluid retention (e.g. swollen ankles). Storage Information Do not store above 30°C, store in the original carton. Shelf life: 36 months Drug Interactions These medicines may be affected by jazofen, or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines, especially if you are taking: Diuretics (water tablets); Cardiac glycosides, such as digoxin, used to treat heart conditions; Lithium; Zidovudine (an anti-viral drug); Steroids (used in the treatment of inflammatory conditions); Methotrexate (used to treat certain cancers); Medicines known as immunosuppressants such as ciclosporin and tacrolimus (used to dampen down your immune response); Medicines known as selective serotonin reuptake inhibitors (ssris), used for the treatment of depression; Antibiotics called quinolones such as ciprofloxacin; Aminoglycosides (a type of antibiotic); Mifepristone; Any other ibuprofen preparations, such as those you can buy without a prescription; Any other anti-inflammatory pain killer, including aspirin; Cholestyramine (a drug used to lower cholesterol); Medicines known as sulphonylureas such as glibenclamide (usedto treat diabetes); Voriconazole or fluconazole (types of anti-fungal drugs); Gingko biloba herbal medicine (there is a chance you may bleed more easily if you are taking this with jazofen). Ingredients The active substance is ibuprofen
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