Kromafina 4 Mg/5 ml Oral Solution 50 ml

Description

Kromafina contain a medicine called ondansetron. This belongs to a group of medicines called anti-emetics. Kromafina is used for: Preventing nausea and vomiting caused by chemotherapy (in adults and children) or radiotherapy for cancer (adults only). Preventing nausea and vomiting after surgery (adults only). Ask your doctor, nurse or pharmacist if you would like any further explanation about these uses. How to use Do not mix Kromafina with anything (not even water) before swallowing it. To prevent nausea and vomiting from chemotherapy or radiotherapy On the day of chemotherapy or radiotherapy the usual adult dose is 8 mg taken one to two hours before treatment and another 8 mg twelve hours after. On the following days. the usual adult dose is two 5 ml spoonful’s twice a day. this may be given for up to 5 days. Children aged over 6 months and adolescents: The doctor will decide the dose depending on the child’s size (body surface area) or weight. the usual dose for a child is up to one 5 ml spoonful twice a day. this can be given for up to 5 days. To prevent nausea and vomiting after an operation The usual adult dose is four 5 ml spoonfuls before your operation. Children aged over 1 month and adolescents: It is recommended that Kromafina is given as an injection. Patients with moderate or severe liver problems The total daily dose should not be more than 8 mg (two 5 ml spoonfuls). Kromafina should start to work within one or two hours of taking a dose. If you are sick (vomit) within one hour of taking a dose take the same dose again. otherwise, do not take more Kromafina than the label says. If you continue to feel sick, tell your doctor or nurse. Warnings and precautions Do not use Kromafina: If you are allergic (hypersensitive) to ondansetron or any of the other ingredients of this medicine (listed in section 6). You are taking apomorphine (used to treat Parkinson’s disease). If you are not sure, talk to your doctor, nurse or pharmacist before taking Kromafina. Warnings and precautions Check with your doctor, nurse or pharmacist before taking Kromafina if: You have ever had heart problems (e.g. congestive heart failure which causes shortness of breath and swollen ankles). You have an uneven heart beat (arrhythmias). You are allergic to medicines similar to ondansetron, such as granisetron or palonosetron. You have liver problems. You have a blockage in your gut. You have problems with the levels of salts in your blood, such as potassium, sodium and magnesium. Side Effects Allergic reactions If you have an allergic reaction, stop taking it and see a doctor straight away. The signs may include: Sudden wheezing and chest pain or chest tightness Swelling of your eyelids, face, lips, mouth or tongue Skin rash - red spots or lumps under your skin (hives) anywhere on your body Collapse. Other side effects include: Very common (may affect more than 1 in 10 people) Headache. Common (may affect up to 1 in 10 people) A feeling of warmth or flushing Constipation Changes to liver function test results (if you take kromafina with a medicine called cisplatin, otherwise this side effect is uncommon). Storage Information Store below 30°C. Do not refrigerate. Keep the bottle upright. Drug Interactions In particular, tell your doctor, nurse or pharmacist if you are taking any of the following medicines: carbamazepine or phenytoin used to treat epilepsy. rifampicin used to treat infections such as tuberculosis (TB). antibiotics such as erythromycin or ketoconazole. anti-arrhythmic medicines used to treat an uneven heart-beat. beta-blocker medicines used to treat certain heart or eye problems, anxiety or prevent migraines. tramadol, a pain killer. medicines that affect the heart (such as haloperidol or methadone). cancer medicines (especially anthracyclines and trastuzumab). SSRIs (selective serotonin reuptake inhibitors) used to treat depression and/or anxiety including fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram. SNRIs (serotonin noradrenaline reuptake inhibitors) used to treat depression and/or anxiety including venlafaxine, duloxetine. Ingredients The active ingredient is ondansetron. The other ingredients are: Citric acid anhydrous, Sodium benzoate, Trisodium citrate dehydrate, sorbitol 70% solution, Strawberry flavor and water. Specifications Kromafina solution is a sugar-free, strawberry flavoured liquid.