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Lipizet is a medicine to lower increased levels of cholesterol. Lipizet lowers levels of total cholesterol, “bad” cholesterol (LDL cholesterol), and fatty substances called triglycerides in the blood. In addition, Lipizet raises levels of “good” cholesterol (HDL cholesterol). Ezetimibe, the active ingredient of Lipizet, works by reducing the cholesterol absorbed in your digestive tract. Lipizet adds to the cholesterol-lowering effect of statins, a group of medicines that reduce the cholesterol your body makes by itself. How to use Always take this medicine exactly as your doctor has told you. Continue taking your other cholesterol-lowering medicines unless your doctor tells you to stop. You should check with your doctor or pharmacist if you are not sure. Before starting Lipizet, you should be on a diet to lower your cholesterol. You should keep on this cholesterol lowering diet whilst taking Lipizet. The recommended dose is one Lipizet 10 mg Tablet by mouth once a day. Take Lipizet at any time of the day. You can take it with or without food. Warnings and precautions Do not take Lipizet if: You are allergic (hypersensitive) to ezetimibe or any of the other ingredients of this medicine (see Section 6: Contents of the pack and other information). Do not take Lipizet together with a statin if: You currently have liver problems. You are pregnant or breast-feeding. Warnings and precautions Talk to your doctor or pharmacist before taking Lipizet. Tell your doctor about all your medical conditions including allergies. Your doctor should do a blood test before you start taking Lipizet with a statin. This is to check how well your liver is working. Your doctor may also want you to have blood tests to check how well your liver is working after you start taking Lipizet with a statin. If you have moderate or severe liver problems, Lipizet is not recommended. Side Effects Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. This is because on rare occasions, muscle problems, including muscle breakdown resulting in kidney damage, can be serious and may become a potentially life-threatening condition. Allergic reactions, including swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing (which requires treatment right away) have been reported in general use. When used alone, the following side effects were reported: Common: abdominal pain; diarrhoea; flatulence; feeling tired. Uncommon: elevations in some laboratory blood tests of liver (transaminases) or muscle (CK) function; cough; indigestion; heartburn; nausea; joint pain; muscle spasms; neck pain; decreased appetite, pain, chest pain, hot flush; high blood pressure. Additionally, when used with a statin, the following side effects were reported: Common: elevations in some laboratory blood tests of liver function (transaminases); headache; muscle pain, tenderness or weakness. Storage Information Do not store Lipizet above 30°C. Drug Interactions Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. In particular, tell your doctor if you are taking medicine(s) with any of the following active ingredients: Ciclosporin (often used in organ transplant patients) Medicines with an active ingredient to prevent blood clots, such as warfarin, phenprocoumon, acenocoumarol or fluindione (anticoagulants) Colestyramine (also used to lower cholesterol), because it affects the way lipizet works Fibrates (also used to lower cholesterol) Ingredients The active substance is ezetimibe.
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