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Nebilet contains nebivolol, a cardiovascular drug belonging to the group of selective beta-blocking agents (i.e. with a selective action on the cardiovascular system). It prevents increased heart rate, controls heart pumping strength. It also exerts a dilating action on blood vessels, which contributes as well to lower blood pressure. It is used to treat raised blood pressure (hypertension). Nebilet is also used to treat mild and moderate chronic heart failure in patients aged 70 or over, in addition to other therapies. How to use Nebilet may be taken before, during or after the meal, but, alternatively, you can take it independently of meals. The tablet is best taken with some water. Treatment of raised blood pressure (hypertension) The usual dose is 1 tablet per day. The dose should be taken preferably at the same time of the day. Elderly patients and patients with a kidney disorder will usually start with ½ (half) tablet daily. The therapeutic effect on blood pressure becomes evident after 1-2 weeks of treatment. Occasionally, the optimal effect is reached only after 4 weeks. Warnings and precautions Inform your doctor if you have or develop one of the following problems: Abnormally slow heartbeat A type of chest pain due to spontaneously occurring heart cramp called prinzmetal angina Untreated chronic heart failure 1st degree heart block (a kind of light heart conduction disorder that affects heart rhythm) Poor circulation in the arms or legs, e.G. Raynaud’s disease or syndrome, cramp-like pains when walking Prolonged breathing problems Diabetes: this medicine has no effect on blood sugar, but it could conceal the warning signs of a low sugar level (e.G. Palpitations, fast heartbeat). Overactive thyroid gland: this medicine may mask the signs of an abnormally fast heart rate due to this condition Allergy: this medicine may intensify your reaction to pollen or other substances you are allergic to Psoriasis (a skin disease scaly pink patches) or if you have ever had psoriasis Side Effects If you experience any of the following symptoms you should contact your doctor or go to the hospital straight away: When Nebilet is used for the treatment of raised blood pressure, the possible side effects are: Common side effects (may affect up to 1 in 10 people): Headache Dizziness Tiredness An unusual itching or tingling feeling Diarrhoea Constipation Nausea Shortness of breath Swollen hands or feet. In a clinical study for chronic heart failure, the following side effects were seen: Very common side effects (may affect more than 1 in 10 people): Slow heart beat Dizziness Common side effects (may affect up to 1 in 10 people): Worsening of heart failure Low blood pressure (such as feeling faint when getting up quickly) Inability to tolerate this medicine A kind of light heart conduction disorder that affects heart rhythm (1st degree av-block) Swelling of the lower limbs (such as swollen ankles). Storage Information Do not store above 30°C. Store in the original package. Drug Interactions Always tell your doctor if you are using or receiving any of the following medicines in addition to Nebilet: Medicines for controlling the blood pressure or medicines for heart problems (such as amiodarone, amlodipine, cibenzoline, clonidine, digoxin, diltiazem, disopyramide, felodipine, flecainide, guanfacin, hydroquinidine, lacidipine, lidocaine, methyldopa, mexiletine, moxonidine, nicardipine, nifedipine, nimodipine, nitrendipine, propafenone, quinidine, rilmenidine, verapamil). Sedatives and therapies for psychosis (a mental illness) e.g. barbiturates (also used for epilepsy), phenothiazine (also used for vomiting and nausea) and thioridazine. Medicines for depression e.g. amitriptyline, paroxetine, fluoxetine. Medicines used for anaesthesia during an operation. Ingredients The active substance is nebivolol. The other ingredients are: lactose monohydrate, polysorbate 80 (E433), hypromellose (E464), maize starch, croscarmellose sodium (E468), microcrystalline cellulose (E460), silica colloidal anhydrous (E551), magnesium stearate (E572). Specifications White, round, cross-scored tablets in packs of 28 tablets.
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