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This medicine is a contraceptive vaginal ring used to prevent pregnancy. Each ring contains a small amount of two female sex hormones – etonogestrel and ethinylestradiol. The ring slowly releases these hormones into the blood circulation. Because of the low amount of hormones that is released, Ethinylestradiol, Etonogestrel ring is considered a low-dose hormonal contraceptive. Since Ethinylestradiol, Etonogestrel ring releases two different types of hormones it is a so-called combined hormonal contraceptive. How to use You can insert and remove Ethinylestradiol, Etonogestrel ring yourself. Your doctor will tell you when to start using Ethinylestradiol, Etonogestrel ring for the first time. The vaginal ring must be put in on the correct day in your monthly cycle and left in place for 3 weeks in a row. Warnings and precautions Tell your doctor: • if you have (or have ever had) a blood clot in a blood vessel of your legs (deep vein thrombosis, DVT), your lungs (pulmonary embolus, PE) or other organs; • if you know you have a disorder affecting your blood clotting - for instance, protein C deficiency, protein S deficiency, antithrombin – III deficiency, Factor V Leiden or antiphospholipid antibodies; • if you need an operation or if you are off your feet for a long time • if you have ever had a heart attack, or a stroke; • if you have (or have ever had) angina pectoris (a condition that causes severe chest pain and may be a first sign of a heart attack) or transient ischaemic attack (TIA – temporary stroke symptoms); • if you have any of the following diseases that may increase your risk of a clot in the arteries: Warnings and precautions: You should let your doctor know: • if a close relative has or has ever had breast cancer; • if you have epilepsy • if you have liver disease (for instance jaundice) or gallbladder disease (for instance gallstones); • if you have Crohn’s disease or ulcerative colitis (chronic inflammatory bowel disease); • if you have systemic lupus erythematosus (SLE - a disease affecting your natural defence system); • if you have haemolytic uraemic syndrome (HUS - a disorder of blood clotting causing failure of the kidneys); • if you have sickle cell anaemia (an inherited disease of the red blood cells); • if you have elevated levels of fat in the blood (hypertriglyceridaemia) or a positive family history for this condition. Hypertriglyceridaemia has been associated with an increased risk of developing pancreatitis (inflammation of the pancreas); • if you need an operation, or you are off your feet for a long time; Side Effects Stop using the product and seek immediate medical attention if you have noticed: Signs of deep vein thrombosis: swelling of one leg or along a vein in the leg or foot especially when accompanied by pain or tenderness in the leg which may be felt only when standing or walking; increased warmth in the affected leg; change in colour of the skin on the leg e.g. turning pale, red or blue. Signs of a pulmonary embolism: sudden unexplained breathlessness or rapid breathing; sudden cough without an obvious cause, which may bring up blood; sharp chest pain which may increase with deep breathing; severe light headedness or dizziness; rapid or irregular heartbeat; severe pain in your stomach. Storage Information Keep Ethinylestradiol, Etonogestrel ring out of the sight and reach of children. Store below 30°C. Store in the original package in order to protect from light and moisture. Drug Interactions Other medicines and Ethinylestradiol, Etonogestrel: Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. These include medicines used for the treatment of: • epilepsy (e.g. primidone, phenytoin, barbiturates, carbamazepine, oxcarbazepine, topiramate, felbamate); • tuberculosis (e.g. rifampicin); • HIV infection (e.g. ritonavir, nelfinavir, nevirapine, efavirenz); • Hepatitis C virus infection (e.g. boceprevir, telaprevir); • other infectious diseases (e.g. griseofulvin); • high blood pressure in the blood vessels of the lungs (bosentan); • depressive moods (the herbal remedy St. John’s wort). Ethinylestradiol, Etonogestrel ring may influence the effect of other medicines, e.g. • medicines containing ciclosporin • the anti-epileptic lamotrigine (this could lead to an increased frequency of seizures)
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