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OMEZYN PLUS is a prescription medicine called a proton pump inhibitor (PPI). OMEZYN PLUS reduces the amount of acid in your stomach. OMEZYN PLUS is used in adults: For 4 weeks to heal ulcers in the first part of the small bowel (duodenal ulcers). Your doctor may prescribe another 4 weeks of OMEZYN PLUS. For up to 8 weeks for healing stomach ulcers. For up to 4 weeks to treat heartburn and other symptoms that happen with Gastro-oesophageal reflux disease (GORD). GORD happens when acid from the stomach backs up into the tube (esophagus) that connects your mouth to your stomach. This may cause a burning feeling in your chest or throat, sour taste, or burping. For up to 8 weeks to heal acid-related damage to the lining of the esophagus (called erosive esophagitis or EE). To maintain healing of the esophagus. It is not known if OMEZYN PLUS is safe and effective if used longer than 12 months (1 year). How to use Take OMEZYN PLUS exactly as prescribed by your doctor. Do not change your dose or stop taking OMEZYN PLUS without talking to your doctor. Take OMEZYN PLUS on an empty stomach at least one hour before a meal. Swallow OMEZYN PLUS Capsules whole with water. Do not use other liquids. Do not crush or chew the capsule. Do not open the capsule and sprinkle contents into food. Do not substitute two 20 mg capsules for one 40 mg capsule of OMEZYN PLUS because you will receive twice the amount of sodium bicarbonate. Talk to your doctor if you have questions. Your doctor may prescribe antibiotic medicines with OMEZYN PLUS to help treat a stomach infection and heal stomach-area (duodenal) ulcers that are caused by bacteria called H. pylori. Make sure you read the patient information that comes with an antibiotic before you start taking it. Short-Term Treatment of Active Duodenal Ulcer 20 mg Once daily for 4 weeks Benign Gastric Ulcer 40 mg Once daily for 4-8 weeks Gastroesophageal Reflux Disease (GORD) Symptomatic GORD (with no esophageal erosions) 20 mg Once daily for up to 4weeks Erosive Esophagitis 20 mg Once daily for 4-8 weeks Maintenance of Healing of Erosive Esophagitis 20 mg Once daily Warnings and precautions Take special care if you Have been told that you have low magnesium, calcium, or potassium levels in your blood Have liver problems Have heart failure Have bartter’s syndrome (a rare kidney disorder) Have any allergies Have any other medical conditions Are pregnant or plan to become pregnant. It is not known if Omezyn plus can harm your unborn baby. Side Effects If you experience any of the following symptoms you should contact your doctor or go to the hospital straight away: The most common side effects with Omezyn plus include: Headache Abdominal pain Nausea Diarrhea Vomiting Gas Other side effects: Serious allergic reactions. Tell your doctor if you get any of the following symptoms with Omezyn plus. Rash Face swelling Throat tightness Difficulty breathing Your doctor may stop Omezyn plus if these symptoms happen. Storage Information Do not store above 30°C. Keep in the original pack to protect from light and moisture .Keep tightly closed. In use instructions: use during 28 days after first opening. Drug Interactions Especially tell your doctor if you take: Diazepam (valium®) Warfarin (coumadin® jantoven) Phenytoin (dilantin®) Ciclosporin (gengraf, neoral, sandimmune) Disulfiram (antabuse®) A benzodiazepine medicine Ketoconazole (nizoral®) An antibiotic that contains ampicillin Products that contain iron Digoxin (lanoxin®) Voriconazole (vfend®) Atazanavir (reyataz®) Nelfinavir (viracept®) Tacrolimus (prograf®) Saquinavir (fortovase®) Clarithromycin (biaxin®, biaxin xl) Clopidogrel (plavix®) St. John’s wort (hypericum perforatum) Rifampin (rifater, rifamate, rimactane, rifadin) Methotrexate Ingredients The active substances are Omeprazole and Sodium Bicarbonate
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