Vipdomet 12.5/1000 Mg 56 Tablets

Description

Vipdomet contains two different medicines called alogliptin and metformin in one tablet: Alogliptin belongs to a group of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). Alogliptin works to increase the levels of insulin in the body after a meal and decrease the amount of sugar in the body. Metformin belongs to a group of medicines called biguanides which also help to lower blood sugar by lowering the amount of sugar made in the liver and helping insulin to work more effectively. Both of these groups of medicines are “oral antidiabetics”. Vipdomet is used to lower blood sugar levels in adults with type 2 diabetes. Type 2 diabetes is also called non- insulin- dependent diabetes mellitus or NIDDM. Vipdomet is taken when your blood sugar cannot be adequately controlled by diet, exercise and other antidiabetic medicines such as metformin alone; insulin alone; or metformin and pioglitazone taken together. If you are already taking both alogliptin and metformin as single tablets, Vipdomet can replace them in one tablet. How to use The recommended dose is one tablet twice a day. If you have reduced kidney function, your doctor may prescribe a lower dose, which may need to be given as separate tablets of alogliptin and metformin Swallow your tablet(s) whole with water. You should take this medicine with food to reduce your chance of an upset stomach. Warnings and precautions Do not take Vipdomet If you are allergic to alogliptin, metformin or any of the other ingredients of this medicine If you have had a serious allergic reaction to any other similar medicines that you take to control your blood sugar. Symptoms of a serious allergic reaction may include; rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. Additional symptoms may include general itching and feeling of heat especially affecting the scalp, mouth, throat, palms of hands and soles of feet (Stevens-Johnson syndrome). If you have -severely reduced kidney function If you have uncontrolled diabetes, with, for example, severe hyperglycaemia (high blood glucose), nausea, vomiting, diarrhoea, rapid weight loss, lactate acidosis (see “Risk of lactic acidosis” below) or ketoacidosis. Ketoacidosis is a condition in which substances called 'ketone bodies' accumulate in the blood and which can lead to diabetic pre-coma. Symptoms include stomach pain, fast and deep breathing, sleepiness or your breath developing an unusual fruity smell. If you have a severe infection or are seriously dehydrated (have lost a lot of water from your body) If you recently had a heart attack or have severe circulatory problems including shock If you have severe breathing difficulties If you have liver disease Talk to your doctor or pharmacist before taking Vipdomet: If you have type 1 diabetes (your body does not produce insulin). If you are taking Vipdomet with insulin or a thiazolidinedione. Your doctor may want to reduce your dose of insulin or a thiazolidinedione when you take it together with Vipdomet in order to avoid too low blood sugar (hypoglycaemia). If you are taking another medicine for diabetes that contains a “sulphonylurea”, you should not start taking Vipdomet. If you have or have had a disease of the pancreas. In case of symptoms suggestive of liver injury during Vipdomet therapy. Side Effects Stop taking Vipdomet and contact a doctor or the nearest hospital immediately if you notice any of the symptoms of the following serious side effects: Very rare (may affect up to 1 in 10,000 people): Lactic acidosis (a build-up of lactic acid in the blood) is a very serious side effect that may lead to coma. You should also discuss with your doctor if you experience the following side effects: Very common (may affect more than 1 in 10 people): Stomach ache Diarrhoea Loss of appetite Feeling sick Being sick. Storage Information Do not store above 30°C. Store in the original package. Drug Interactions Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. You may need more frequent blood glucose and kidney function tests, or your doctor may need to adjust the dosage of Vipdomet. It is especially important to mention the following: Hydrocortisone and prednisolone (corticosteroids), used to treat diseases that involve inflammation like asthma and arthritis Cimetidine, used to treat stomach problems Bronchodilators (beta-2 agonists), used to treat asthma Medicines which increase urine production (diuretics) Medicines used to treat pain and inflammation (NSAID and COX-2-inhibitors, such as ibuprofen and celecoxib), Certain medicines used for the treatment of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists) Medicines containing alcohol. Ingredients The active substances are alogliptin benzoate and metformin hydrochloride. Specifications Vipdomet 12.5 mg/1000 mg Film-coated Tablets are pale yellow oblong biconvex film-coated tablets with “12.5/1000” debossed on one side and “322M” debossed on the other side in aluminum/aluminum blisters.