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Lorinase-D Extended Release Tablets is a medicinal product contains two active substances: Desloratadine and Pseudoephedrine. Desloratadine is a potent antihistamine with selective peripheral H1-receptor antagonistic activity. Pseudoephedrine sulfate, one of the naturally occurring alkaloids of Ephedra and an orally administered vasoconstrictor, produces a gradual but sustained decongestant effect facilitating shrinkage of congested mucosa in upper respiratory areas. The mucous membrane of the respiratory tract is decongested through the action of the sympathetic nerves. Lorinase-D Extended Release Tablets relieves symptoms associated with allergic rhinitis (hay fever) in adults and adolescents 12 years of age and older, such as: Nasal and sinus congestion. Sneezing. Runny nose. Watery, itchy eyes. How to use How much to take Take Lorinase-D Extended Release Tablets exactly as your doctor tells you to take it. Lorinase-D Extended Release Tablets can be taken with or without food. Swallow Lorinase-D Extended Release Tablet whole. Do not break, crush, or chew Lorinase-D Extended Release Tablet before swallowing. If you cannot swallow Lorinase-D Extended Release Tablet whole, tell your doctor. You may need a different medicine. Take 1 Lorinase-D Extended Release Tablet 2 times a day (every 12 hours). Do not use in children under 12 years of age. Warnings and precautions Do not take Lorinase-D Extended Release Tablets if you: Have an allergy to Lorinase-D Extended Release Tablets or any of the ingredients listed at the end of this leaflet. Are allergic to loratadine. Have narrow-angle glaucoma. Have problems with urination (urinary retention). Take a Monoamine Oxidase Inhibitor (MAOI) medicine to treat depression, or if you stopped taking an MAOI medicine within the last 2 weeks. Ask your doctor or pharmacist if you are not sure if you take an MAOI medicine. Have severe high blood pressure. Have severe heart disease. Talk to your doctor before taking this medicine if you have any of these conditions. Before you start to take it, tell your doctor or pharmacist if you: Have diabetes Have hyperthyroidism Have prostate problems Have liver or kidney problems Have any other medical conditions Are pregnant or plan to become pregnant. It is not known if Lorinase-D Extended Release Tablets will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Are breastfeeding or plan to breastfeed. Lorinase-D Extended Release Tablets can pass into your breast milk. Talk to your doctor about the best way to feed your baby if you take Lorinase-D Extended Release Tablets. Side Effects Lorinase-D Extended Release Tablets may cause serious side effects, including: Cardiovascular and central nervous system effects, such as Unable to sleep (insomnia) Dizziness Weakness Tremor Irregular heart beat Seizure Low blood pressure Increased sleepiness or tiredness can happen if you take more Lorinase-D Extended Release Tablets than your doctor prescribed to you. Allergic reactions. Stop taking Lorinase-D Extended Release Tablets and call your doctor right away or get emergency help if you have any of these symptoms: rash itching hives swelling of your lips, tongue, face, and throat shortness of breath or trouble breathing Severe skin reactions including signs and symptoms such as fever, reddening of the skin, or many small pimples Rarely: sudden onset of severe headache, nausea, vomiting or visual disturbances which may be symptoms of conditions known as Posterior Reversible Encephalopathy Syndrome (PRES) or Reversible Cerebral Vasoconstriction Syndrome (RCVS). The most common side effects of Lorinase-D Extended Release Tablets include: Unable to sleep (insomnia) Sore throat Headache Dizziness Dry mouth Nausea Tiredness Loss of appetite Sleepiness Tell your doctor if you have any side effect that bothers you or that does not go away. Storage Information Store below 30°C. Drug Interactions Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal supplements. Lorinase-D Extended Release Tablets may affect the way other medicines work, and other medicines may affect how Lorinase-D Extended Release Tablets works. Especially tell your doctor if you take: Monoamine Oxidase Inhibitors (MAOIs). You should not use Lorinase-D Extended Release Tablets if you take an MAOI or within 2 weeks of stopping an MAOI. Methyldopa Reserpine Digoxin, ketoconazole erythromycin azithromycin antihistamines other decongestant medicines Specifications Lorinase-D Extended Release tablet is a round, flat beveled edge, uncoated bilayer tablet, having mottled on blue color with "276" at one side and white plain surface on the other side.
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